Eagles-Chargers Monday Night Football Week 14 Preview: Odds, Lines, Best Bets

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Game overview

The Eagles and Chargers both face some uncertainty about the health of key players in the lineup. This matchup could depend on who is missing the most players.

For the Chargers, the status of Justin Herbert, who recently underwent a procedure on his non-throwing hand, will be crucial. Without Herbert, the Chargers would have to start Trey Lance behind a patchwork offensive line that has struggled to keep quarterbacks off the ground this season after allowing the most quarterback knockdowns (102) in the NFL.

However, the expected return of first-round running back Omarion Hampton to the lineup can do a lot to alleviate the pressure from the Chargers’ passing game. Prior to Hampton’s injury in Week 5, the freshman back had the fourth-highest PFF rushing grade (83.3) in the NFL. That asset helped the Chargers win three of their first five games while Hampton played.

For the Eagles, injuries have hit hard on both sides of the ball, both with Jalen Carter and the club Lane Johnson has been ruled out for Week 14. Needless to say, these losses will prove difficult to overcome. The betting markets back this up, with the Eagles having an 0-4 record against the spread in games in which either has missed – including each of the past two weeks, in which Johnson has been absent. Now Philadelphia will have to navigate missing both highlights.

That important fact is one that gambling analyst Ben Linsey highlighted this week on the PFF Betting Show with his pick of Chargers moneyline. The line continues to move toward the Chargers, but still profiles as an angle that the PFF simulation model agrees with, with a projected value of 2.8%.

WR A.J Brown, Philadelphia Eagles: Less than 62.5 receiving yards (-114)

Brown’s recent resurgence has been a positive turn for this Eagles offense, with the veteran receiver racking up over 110 yards through the air in each of the last two games. Still, those performances came against a pair of struggling secondaries in the Cowboys and Bears. This matchup against the Chargers defense presents a significantly more difficult task.

The Chargers have done well to limit receiver production this season, surrendering the third-fewest yards to the position in 2025. This unit is particularly strong and features pass catchers from wide lineups, allowing just 7.0 yards per coverage target – also the third-lowest mark in the NFL.

Los Angeles’ defense also deserves credit for its ability to keep the ball in front of it and neutralize explosive catches. The Chargers’ 46 receptions of 15 or more yards passed the ranks above the NFL.

To make this task even more difficult, this matchup doesn’t bode well for Brown schematically. The Chargers have the fourth-highest percentage of zone coverage, with a focus on Cover-3 and quarters. Brown is significantly less effective when it comes to zone coverage than humans, and has the second largest PFF grade difference between the two.