Alzheimer’s influences memory and cognitive functions, influences the ability to speak and think, but it can also cause other problems, such as states of confusion, mood changes and disorientation in space. Suffering in the world of a form of dementia are more than 55 million people, including 1.2 million in Italy (where, according to estimates, they will be 2.3 million by 2050). In 60/70 percent of the cases it is Alzheimer’s disease (AD). According to experts, the CEO touches the brain long before it manifests itself with clear clinical symptoms. This is why when the diagnosis arrives, the disease has already affected memory and cognitive functions, and it is probably also the reason why the few approved or experiments of medicines have minimal, if not zero effects.
Dr. Daniel Amen, a Californian psychiatrist and researcher expert in dementia, reveals the 4 early signs of the disease that can manifest themselves for decades before the clinical symptoms, and to pay attention to an early diagnosis. “Diagnosis of the disease in time is the only way we have – explains the expert – to curb the advance of the advertisement, even today there is not a concern that blocks its progression”.
The first early signal
The first and most common early sign of Alzheimer’s is the progressive deterioration of the memory. “Eighty percent of people who have seen their memory worse their memory in the last 10 years have 80 percent of the possibilities that you continue to deteriorate”. According to the National Institute of Aging (US), The memory problems associated with the initial phase of Alzheimer’s include “a deterioration of non -Mnemonic cognitive aspects, such as the difficulty of finding the right word, difficulty understanding visual images and space traffic and difficulties in reasoning or in the judgment”. “As the disease progresses – Amen explains – the symptoms become more serious and the confusion increases as behavioral changes”.
The second early signal
The second alarm is the poor power of judgment and impulsivity. According to the expert this happens because the activity of the frontal lobes (fundamentally for the planning and implementation of acquired and deliberate behavior, and also the seat of many inhibiting functions) is reduced by the disease. “It’s a bit like the brain is offline,” Amen explains. Only about 1 of 50 out of 50 affected by Alzheimer’s disease discovers that the forobes are influenced early. When this happens, the condition is known as the “front variant of Alzheimer’s disease” (FVAD).
The third early signal
The third early symptom of the disease is a reduction in the ability of attention with a resulting increase in distracting itself, which should not be confused with the ADHD. “The disruption of activity and attention (ADHD) – explains the expert – is a condition that accompanies the person throughout life, in the case of Alzheimer’s a progressive deterioration over time”.
“Alzheimer’s disease – explains Ruth Drew, director of family services and information at theAlzheimer’s Association – The brain attacks and tends to start in the Hippocampus, where new memories and new learning are stored. That is why everything that interrupted this area would certainly make it more difficult for a person to maintain a stream of thoughts. It is different for every person. But in the intervening phases of the disease, the concentration will certainly be influenced “.
The fourth early signal
A fourth early plate is the bad mood and feel depressed. “Living with dementia – explains Amen – can lead to feelings of deep sadness or despair. It is added that the disease can damage parts of the brain involved in emotions and behavior.”
The predictive signals that appear 18 years earlier
To have investigated the predictive signals from Alzheimer’s, a recent study led by the Innovation Center for Neurological Disorders of Beijing (China) and published on New England Journal of Medicine. The researchers have discovered from the analysis that the first sign of this form of dementia is an accumulation of the beta-amyloid protein in the cerebrospinal fluid (one of the distinctive neuropathological signs of the disease), clearly between 18 and 14 years before the diagnosis of the Tau-Fospholid of the Tau-Phospholid of the Tau-Phospholid of the Tau-Phospholid of the Tau-Phospholid of the Tau-Phospholid Tau-phospholidation of the tau phospholidation of the tau phospholidation of the tau phospholidation of the tau phospholidation of the tau phospholidation of the tau-phospholidation of the tau phospholidation of the tau-phospholidation of the tau-phospholido. These signals follow the appearance of neuronal damage caused by the presence of a protein, the light neurophophophophophophuric chain, in the cerebrospinal liquid, clearly 9 years before the diagnosis, and an atrophy of the hippocampus, part of the brain that is already 8 -year -old. Finally, 6 years after the diagnosis, in patients with Alzheimer’s, a clear cognitive decline in dementia tests arose.
The factors that increase the risk of Alzheimer’s
Dr. Amen has also mentioned some of the factors that can increase the chance of developing the disease. “Depression doubles the risk of Alzheimer’s in women and quadrupules in men. But being overweight or obviously also increases the risk. As the weight increases, the size and functionality of the brain decrease”. “Other disorders that can lead to poor brain health – he concludes – his erectile dysfunction (because if you have bloodstream problems everywhere, it means they are everywhere), chronic insomnia and night apnea.”
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