An anonymous reader quotes a report from ScienceAealert: A genetically modified pig -long -long transplanted into a brain -dead human patient functioned for nine days in a new performance that reveals both the promise and important challenges of Xenotransplantation. In the course of the experiment, the patient showed increasing signs of organ reduction before scientists ended the experiment in the first affiliated hospital of Guangzhou Medical University in China, allowing the recipient to die. It is the First time a pig -long lung has been transplanted into a human patientProviding an important step forward and giving scientists new problems to solve while they are further developing this emerging medical technique. […]
The goal of the experiment was not to achieve a successful transplant in the first attempt – that would have been pretty incredible, but not a realistic expectation. Instead, the researchers wanted to observe how the patient’s immune system reacted to the transplanted organ. The patient was a 39-year-old man who was explained by four separate clinical assessments after undergoing a brain haemorrhage. His family gave written permission for the experiment. The donor pig is known as a six-gene edited pig, a Bama miniature pig with six Crispr genes, housed in an isolated facility with rigorous disinfection protocols. These operations are all aimed at minimizing the patient’s immune and inflammatory reactions.
In a careful surgical procedure, the left lung of the pig in the patient’s chest cavity was placed and connected to their airways, arteries and veins. The paper does not explain the fate of the pig, but donor rans usually do not survive the removal of a large organ. The patient was also treated with a number of immunosuppressants that the researchers adapted over time to changes observed in the patient’s body. Initially it all seemed good, with none of the immediate signs of hyperacute rejection in the critical few hours after the procedure. However, by 24 hours after the transplant took place, serious swelling (edema) was observed, possibly as a result of the blood flow that was restored to the area of the transplant. Antibody-mediated rejection further damaged the tissue on days three and six of the experiment. The result of the damage was primary transplant disease function, a type of severe long injury that took place within 72 hours after a transplant and the most important cause of death in patients with lung transplantation. What recovery took place by day nine, but the experiment had run its course. The investigation has been Published in Nature Medicine.
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