The most intriguing rivalry of the 2025-26 NBA campaign will add a new chapter when the Oklahoma City Thunder and San Antonio Spurs face off again Wednesday night in San Antonio. Oklahoma City (40-11) won the most recent meeting at home on Jan. 13, but San Antonio (33-16) still leads the head-to-head series on the season 3-1.
Let’s take a look at my Thunder vs. Spurs predictions.
Oklahoma City Thunder vs. San Antonio Spurs Odds
Moneyline: Thunder -130 / Spurs +110
Spread: Thunder -2.5 (-105) / Spurs +2.5 (-115)
Total: Over 226.5 (-110) / Under 226.5 (-110)
Oklahoma City Thunder vs. San Antonio Spurs Best Bet No. 1: Spurs +2.5 (-115)
This is a great spot for the Spurs, especially as small underdogs. They crushed the Thunder 130-110 when these two rivals last collided on December 23 in San Antonio. Additionally, OKC is playing the second leg of a back-to-back after getting the best of Orlando at home on Tuesday night. To make matters worse for the visitors, Jalen Williams will likely miss his ninth straight game due to a hamstring issue. Williams is averaging 16.8 points, 5.6 assists and 4.8 rebounds per game, so his absence would obviously be crucial.
The Thunder have cooled off lately, in part because they’ve been without Williams. The defending champions still have the best record in the association, but are just 3-4 in their last seven games and 5-5 in their last ten. San Antonio is 6-3 in its last nine games and has lost just once at home since Jan. 3. Victor Wembanyama has scored 25 points or more in five of the last eight games and blocked four shots or more in four of the last five. Don’t be surprised if the home team wins this one outright.
Oklahoma City Thunder vs. San Antonio Spurs Best Player Prop Bet: Dylan Harper Over 9.5 points (-115)
Here comes Dylan Harper! It’s taken a while for the No. 2 overall pick to get going in his NBA career, but the rookie is heating up as we approach the all-star break. He has scored 16, 20 and 15 points in the last three games, consistently destroying his season average of 10.7 ppg.
Harper has scored 12 points in each of the last two head-to-head games with Oklahoma City. He should be in line for another successful night on Wednesday, in part because fellow shooting guard Stephon Castle is in danger of missing his second straight game due to a thigh injury. Castle is questionable, so he will be sidelined or perhaps placed on a minutes restriction. Either way, Harper should get plenty of time in court.
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