Michigan vs. Duke odds, prediction, time: 2026 college basketball picks for Feb. 21 from proven model

An elite non-conference matchup is scheduled for Saturday as the No. 3 Duke Blue Devils take on the top-ranked Michigan Wolverines in the 2026 Edwards Jones Capital Showcase. Michigan is 25-1 this season with its lone loss coming against Wisconsin. The Blue Devils are 24-2, falling only to Texas Tech and UNC. Both programs are projected as the No. 1 seed in CBS Sports’ latest NCAA Tournament bracketology.

Tipoff in Washington DC is scheduled for 6:30 PM ET. After opening at -1.5, the Wolverines are 2.5 point favorites in the latest Michigan vs. Duke odds, while the over/under is 150.5. Before you make a choice between Duke and Michigan, check out the men’s basketball predictions and betting advice from the SportsLine projection model.

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The SportsLine projection model simulates every college basketball game 10,000 times and entered Week 16 on a blistering 11-1 run on last season’s top-rated over/under college basketball picks, and is on a 13-7 run on top-rated CBB side picks. Anyone who followed the college basketball betting advice on sportsbooks and betting apps could have seen strong returns.

Now the model has been simulated Michigan vs. Duke 10,000 times and just unveiled the coveted men’s basketball picks and betting predictions. That’s possible head over to SportsLine now to see the model’s picks. Here are several men’s college basketball odds and men’s college basketball betting odds for Duke vs. Michigan:

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Top Duke vs. Michigan Predictions

The SportsLine model is Moving on to the total (150.5 points). Michigan’s offense is historically strong as the Wolverines average 90.6 points per game. They have fielded a balanced attack with five players averaging at least 10 points per game, and Yaxel Lendeborg leads the way with 14.4 points per game. The Wolverines have seen the total clear in three of their past five games.

Duke is averaging 83 points per game, and it’s freshman Cameron Boozer doing most of the heavy lifting, averaging 22.8 points per game. The SportsLine model projects 155 combined points in this matchup, with the Over releasing in 61% of simulations.

How to watch Michigan vs. makes Duke choices

The model also says that one side of the spread hits well over 60% of the time. You will only see that choice at SportsLine.

So who wins Duke vs. Michigan and which side of the spread hits over 60% of the time? Visit SportsLine now to see which side of the spread to back, all from the advanced model that has simulated this game 10,000 timesand find out.