Non-League Macclesfield stunned Crystal Palace yesterday and Mikel Arteta will be wary of underestimating Pompey in what will be a hostile atmosphere at Fratton Park.
Arteta is expected to make the changes, but Arsenal should still have enough to comfortably secure a place in the fourth round.
Arsenal are six points clear at the top of the Premier League and this is the first of four away games in four competitions in nine days for the Gunners, who are aiming for a record 14th FA Cup trophy this season.
They were knocked out at this stage by Manchester United last season and Arteta will be eyeing the first round of the Carabao Cup semi-final with Chelsea next week.
But Arteta will demand a professional performance from either side.
How to watch Portsmouth vs Arsenal
TV channel: In the UK, the match will be broadcast live on TNT Sports 1, with coverage from 1.30pm, ahead of the 2pm kick-off.
Live stream: TNT Sports subscribers can also follow the match live online via the Discovery+ app and website.
Live blog: You can follow all the matchday action via Standard sport‘s live blog, with expert analysis from Fratton Park’s Matt Verri.
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