A single faecal microbiota transplantation in obese teenagers provided long-term metabolic benefits, shrinking waist, reducing body fat and inflammation and reducing heart disease risk markers, which were visible four years later.
We have previously treated faecal transplant studies. Although it might not be a suitable subject for the dining table, the increase in research acknowledges the importance of the intestinal microbiome on almost the whole The body has shown an spotlight on the treatment.
Eight years ago, 87 adolescents participated in a groundbreaking study led by the University of Auckland, New Zealand, in which they received a single fecal microbiota transplantation (FMT) to treat their obesity. The researchers have now published the results of their follow -up research, carried out more than four years later.
“What is impressive is that only a single FMT treatment resulted in a dramatic reduction in metabolic syndrome that lasted at least four years,” said Wayne Cutfield, MDA professor in pediatric endocrinology at the Liggins Institute At the University of Auckland and the co-racking author of the study. “This means that participants in the long term run a much lower risk of developing diabetes and heart disease.”
The seven -like obese adolescents that were recruited in the trial were between 14 and 18 years old. Half received fmt-capsules-ja, taken by mouth-made from healthy, lean donors. The others received placebo capsules. Participants in the treatment group swallowed 28 capsules in two days, each with intestinal bacteria of four donors. During the first six months, the test was a double-blind, randomized placebo-controlled study. After that the participants were over (that is, they knew if they had received a treatment or a placebo) but followed four years later.
After about four and a half years, 55 participants (63% of the original group) came back for checks with Dexa lectures, blood tests, blood pressure measurements, food and activity questionnaires and relief samples for intestinal microbiomo analysis. A Dexa (Dual-Energy RöntgenabsortriTiometry) scan is a non-invasive medical imaging test that uses X-rays with low dose to accurately measure the bone density of a person, total body fat and lean muscle mass.
The researchers discovered that although there were no significant differences in weight and body mass index (BMI) between the FMT and placebo groups, those who had had FMT, had smaller waist (on average 10 cm/3.9) and about 5% less total body fat at follow-up. They had lower severity scores for metabolic syndrome, much lower inflammation and higher levels of “good” HDL cholesterol. No big difference was seen in the control of blood sugar levels or most other cholesterol and lipida markers.
“More than one in three of the original teenage participants in our studies had metabolic syndrome,” said Cutfield. “Metabool syndrome has serious consequences, including a doubling of the risk of death due to heart disease or stroke and a five -time increased risk of type 2. diabetes
Amazingly enough, FMT led to long -term changes in intestinal bacteria and viruses. The bacterial and viral tribes that participants had taken in the treatment group from donor were still present after four years. Some participants retained many donor tensions, others very little.
“It really makes us think about the timetables that we are looking for the effects of microbiome -based treatments,” said the other accompanying author of the study, Professor Justin O’Sullivan, PhDDirector of the Liggins Institute. “Imagine that you can program your microbiome to reduce the risk of circumstances before they occur. This work has been released for probiotics of the next generation that focus on specific circumstances due to persistent changes in the microbiome.”
Commercialization of a microbiome -based treatment for metabolic syndrome is the end goal of the researchers.
“Our holy grail is to develop a super mix of bacteria that can be taken to prevent or moderate metabolic syndrome,” said Cutfield. “The first step is to prove that our customized combination of bacteria really works.”
The study was published in the magazine Nature communication.
Source: University of Auckland
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