Thursday Night Football: Philadelphia Eagles-New York Giants betting preview (odds, lines, best bets)

• Brian Daboll’s Giants are no strangers to being underdogs: Since hiring Daboll as head coach in 2022, the Giants have been underdogs 23 times in the betting at MetLife Stadium. That is the highest number of all active head coaches in that period.

• Cam Skattebo’s impact in the receiving game: The freshman running back has ample opportunity to make his mark in this game amid a slew of injuries to the Giants’ pass catchers. This makes his line of 2.5 receptions very feasible.

Game overview

We kick off Week 6 with an NFC East showdown between the defending Super Bowl champion Eagles, fresh off their first loss of the 2025 season, and a Giants team looking to build momentum behind its young core.

This matchup has been lopsided in recent years, with Philadelphia dominating the rivalry. Since Brian Daboll took over as head coach in 2022, the Eagles are 6-1 against the Giants. However, the gambling results are more evenly distributed. The Giants are 3-4 against the spread during that stretch – all as underdogs – while Philadelphia has defeated just two of the four games in which it has been favored by seven or more points.

The 2025 season has followed a familiar script for the Eagles: favored in every game so far, they’ve posted a 3-2 record against the spread. That modest coverage percentage is more impressive when you consider the difficulty of their schedule, which included four straight games against 2024 playoff teams. That stretch included road surfaces in both Kansas City and Tampa Bay.

Philadelphia remains a top team, powered by a defense that ranks fifth overall (75.2). However, offensive efficiency has declined, leading to tighter games that are often decided by close margins or crucial special teams plays. The Eagles rank outside the top half of the league in several key offensive categories: 25th in positive EPA play percentage, 19th in success rate and 23rd in scoring percentage.

For the Giants, the betting markets have moved in the opposite direction: They enter Week 6 as underdogs for the sixth straight game to start the season. No team has been an underdog more often than New York under Brian Daboll, whose 23 such games since 2022 led all active head coaches. They are 2-3 against the spread this year, with their only outright win at home against the Chargers in Week 4.

If the Giants want to pull off the upset, they’ll need a big performance from their pass rush – the NFL’s seventh-highest rated unit (80.0). The Eagles may be without guard Landon Dickerson, who left Week 5 with an ankle injury. Without him, Philadelphia’s protection faltered, surrendering six sacks and 35.6% pressure to Denver’s defensive front.

RB Cam Skattebo, New York Giants: over 2.5 receptions (+120)

Skattebo has taken the NFL by storm and has quickly become an indispensable part of the Giants’ offense – a role that is only becoming more important due to increasing injuries at wide receiver.

With Malik Nabers lost in Week 4 this season and Darius Slayton sidelined last week (and likely this week), New York faces a tough matchup shorthanded and likely playing from behind.

That sets the stage for Skattebo to see continued involvement in the passing game, just as he did against the Saints when he caught all six of his targets, making Theo Johnson the team leader. It was his second six-catch performance since his role expanded.

While the return of Tyrone Tracy could negatively impact Skattebo’s early work, it is unlikely to impact his usage as a receiver. Skattebo has the third-highest PFF grade (81.6) among running backs this season – a stark contrast to Tracy’s grade of 39.9 since the start of last year.