The intestinal bacteria of your body have its own ozempic-like system, suggests a study, and scientists believe that manipulating weight loss can solve without the nasty side effects of the medicine.
Researchers at Duke University in North Carolina have discovered specialized bacteria and cells in the colon that can send signals to the brain to determine how much you eat and to curb the appetite of appetite, similar to how weight loss drugs work.
In the animal study, the scientists discovered that during dinner a gut bacterium that is known as Flagella flagelline protein releases that then produces a hormone that is called Pyy.
When the body feels full or has reached the satisfaction of the food, the Pyy -Hormone warns the neurobiotic feeling of the colon, a direct communication duct between the intestine and the nervous system, to stop the brain to stop eating in real time and to prevent a person from consuming excessive calories.
The scientists discovered that when this bacterial detection system breaks down, people tend to eat more food and arrive considerably more than people with a fully functioning system, which can lead to Obesity.
As a result, they concluded that this unique system naturally mimics the appetite-suppressing effects of GLP-1 drugs in the body and help control the weight gain.
They also believe that manipulating the bacteria system and improving natural communication, via certain diets or by taking prebiotics and probiotics can help with weight loss.
Senior author Diego Bohórquez, assistant professor of medicine and neurobiology at the university, said: “Looking ahead, I think this work will be especially useful for the broader scientific community to explain how our behavior is influenced by microbes.”
Duke University researchers have discovered colon bacteria and cells that mimic ozempic
He continued: “We were curious if the body could feel microbial patterns in real time and not only as an immune or inflammatory response, but as a neural reaction that leads behavior in real time.”
The study, which was published in NatureTested the intestinal mechanism on two groups of mice: one that had the receptors for the Pyy hormone in their gut, known as TLR5, and another who did not.
Both groups of mice fast at night and received a small dose of flagellin the next day directly in the colon.
The mice with TLR5 receptors in their intestine ate less the next day, while those without larger meals have consumed and were given more weight.
The increased food consumption was seen in both male and female mice.
Although the results still have to be replicated in people, the scientists concluded that the flagelline could activate cells in the gut to send a appetite-oppressive signal to the brain.
According to the researchers, the most important player in the Flagellin system is.
When excessive amounts of food are consumed, the intestinal bacteria release large quantities of flagelline in the colon, which in turn sends more urgent signals to the brain to stop eating.
The scientists noted that without the TLR5 receptors and the ‘we have enough’ signal from the gut, the person continues to eat without realizing that they are full.
The results indicated that the presence of TLR5 receptors in the cells of the intestine and the production of the Pyy hormone as the natural ‘stop eating’ signal of the body acts.
Scientists say that this system mimics the effects of GLP-1 drugs and can help in control weight gain
Displayed: Flagella, a intestinal bacterium that releases the flagelline protein and releases Pyy -Hormone
The authors of the study wrote: ‘It is similar to how we use our other senses – visibility, sound, smell, taste and touch – to interpret our world. But this works from an unexpected place: the intestine. ‘
Based on these results, the scientists hope to further understand how the intestine detects microbes and influence everything, from eating habits to mood.
Popular weight loss medicines such as Semaglutide (Ozempic) and Tirzepatide (Mounjaro) focus on brain chemistry and suppressing appetite, but they can also lead to long -term side effects and damage to vital organs such as liver, kidneys and thyroid gland.
The discovery of the ‘sixth feeling’ of the intestine of food consumption, as well as the possibility of increasing the presence of flagella through dietary changes or supplements, can help people lose weight naturally without suffering the extreme side effects of GLP-1 weight loss medicines.
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