Gain an edge in your NFL pick-em contests with our data-driven NFL Week 16 continues immediatelypowered by thousands of game simulations.
Week 16 of the NFL season kicks off on Thursday night with the Los Angeles Rams facing the Seattle Seahawks and concludes with the San Francisco 49ers versus the Indianapolis Colts on Monday night.
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The full NFL Week 16 list will surface immediately
- Rams (57% chance of winning)
- Eagles (68%)
- Packers (59%)
- Bills (85%)
- Cowboys (60%)
- Saints (67%)
- Buccaneers (62%)
- Vikings (58%)
- Leaders (64%)
- Bengal (58%)
- Broncos (59%)
- Falcons (56%)
- Texans (93%)
- Lions (71%)
- Raven (57%)
- 49ers (70%)
NFL picks immediately this week: Week 16, 2025
Below are our Week 16 NFL picks, which highlight each team’s chances of winning their game this week.
Los Angeles Rams vs Seattle Seahawks
The Rams kick off Week 16 on Thursday night against the Seahawks at Lumen Field. According to our NFL model, the Aries have a 57% chance of winningwhile the Seahawks have a 43% chance.
For the opening game of Week 16, our model highlights NFL players’ props with Kyren Williams (RB) as the Rams’ most likely player to score the first TD at 12.0%, while Jaxon Smith-Njigba (WR) is the Seahawks’ top prospect at 10.4%.
The Los Angeles Rams vs Seattle Seahawks game at Lumen Field is scheduled for Thursday, December 18 at 8:15 p.m. All times in this article are in Eastern Standard Time (EST).
Philadelphia Eagles vs. Washington Commanders
For this week’s game between the Eagles and Commanders, Philadelphia is more likely to win. Our prediction model gives the Eagles have a 68% chance of winning. On the other hand, there is a 32% chance that the Commanders will win.
The Philadelphia Eagles vs. Washington Commanders The match at Northwest Stadium will take place on Saturday, December 20 at 5:00 PM.
As the playoffs approach, keep up with the top teams with Dimers’ updated NFL Futures, highlighting the top Super Bowl contenders.
Green Bay Packers vs. Chicago Bears
We pick the Packers to win their game against the Bears this week, with our powerful NFL model projecting a 59% win probability for the road team. The Bears have a 41% chance of winning.
For betting purposes, the Bears are listed as +1.5 underdogs, with the Packers’ moneyline at -112.
The Green Bay Packers vs. Chicago Bears The game at Soldier Field is scheduled for Saturday, December 20 at 8:20 PM.
Buffalo Bills vs. Cleveland Browns
According to our predictive analytics model, the Bills are the team to beat in this game, with an 85% chance of winning. The Browns, on the other hand, have a 15% chance of winning.
The Buffalo Bills-Cleveland Browns game at Huntington Bank Field is scheduled for Sunday, December 21 at 1 p.m.
Los Angeles Chargers vs. Dallas Cowboys
The Cowboys have a 60% chance of winning on Sunday afternoon, compared to the Chargers’ 40% chance of winning. This makes the Dallas Cowboys our pick to win at AT&T Stadium.
The Los Angeles Chargers vs. Dallas Cowboys game at AT&T Stadium is scheduled for Sunday, Dec. 21 at 1 p.m.
New York Jets vs. New Orleans Saints
The Saints are favorites to win their Week 16 matchup, with our predictive analytics model giving them a 67% chance, while the Jets enter the weekend with a 33% chance of causing upset at Caesars Superdome.
When it comes to betting on this game, the Jets’ moneyline odds are set at +185, with the home side Saints listed as -4.5 favorites.
The New York Jets vs. New Orleans Saints game at Caesars Superdome will take place on Sunday, December 21 at 1:00 PM.
Tampa Bay Buccaneers vs. Carolina Panthers
After 10,000 simulations of Buccaneers vs. Panthers this Sunday, our model projects the Buccaneers as the most likely winners with a probability of 62%. Their opponents, the Panthers, have a 38% chance of winning at home.
The Tampa Bay Buccaneers vs. Carolina Panthers game at Bank of America Stadium is scheduled for Sunday, Dec. 21 at 1 p.m.
Minnesota Vikings vs. New York Giants
DimersBOT picks the Vikingswho have a 58% chance of winning the game, while the Giants have a 42% chance of winning.
The Minnesota Vikings vs. New York Giants game at MetLife Stadium will take place on Sunday, December 21 at 1:00 PM.
Kansas City Chiefs vs. Tennessee Titans
In the next game of Week 16, the Chiefs will take on the Titans at Nissan Stadium.
We predict the Chiefs will win with a probability of 64%, while the Titans are projected to have a 36% chance of winning.
As for the Vegas betting odds here, the Titans are listed as +3.5 underdogs, while the Chiefs’ moneyline odds are listed at -178.
The Kansas City Chiefs vs. Tennessee Titans at Nissan Stadium is scheduled for Sunday, December 21 at 1:00 PM.
Cincinnati Bengals vs. Miami Dolphins
The likely winner of this matchup is the Bengalswhich according to DimersBOT have an expected profit chance of 58%. On the other side of this matchup, the Dolphins have a projected win probability of 42%.
The Cincinnati Bengals vs. Miami Dolphins game at Hard Rock Stadium is scheduled for Sunday, Dec. 21 at 1 p.m.
Jacksonville Jaguars vs. Denver Broncos
We ran our high-powered NFL model over this week’s Jaguars-Broncos clash 10,000 times, with the Broncos emerge as the team to pick. Of those 10,000 simulations, the Broncos won 5,891 times, while the Jaguars won 4,109 times.
The Jacksonville Jaguars vs. Denver Broncos at Empower Field at Mile High is scheduled for Sunday, December 21 at 4:05 p.m.
Atlanta Falcons vs. Arizona Cardinals
Next up is the game between the Falcons and Cardinals, where our model projects the road team as the most likely winner, with the According to the assessment, falcons have a 56% chance of reaching the W. The Cardinals, on the other hand, are projected to have a 44% chance of winning.
For those interested in betting on this matchup, the oddsmakers have set the Falcons’ moneyline odds at -140 for this road game, while the host Cardinals are listed as +2.5 underdogs.
The Atlanta Falcons vs. Arizona Cardinals at State Farm Stadium takes place on Sunday, December 21st at 4:05 PM.
Las Vegas Raiders vs. Houston Texans
Our next pick this week is for the Texans to get the win against the Raiders. After running 10,000 simulations of this matchup, the Houston have a 93% win probability, while the Raiders have 7%.
The Las Vegas Raiders vs. Houston Texans at NRG Stadium is scheduled for Sunday, December 21 at 4:25 PM.
Pittsburgh Steelers vs. Detroit Lions
With a 71% chance of winning on Sunday afternoon, our immediate choice for this game is the Lionswhile their opponent, the Steelers, has an expected win probability of 29%.
The Pittsburgh Steelers vs. Detroit Lions at Ford Field takes place on Sunday, December 21st at 4:25 PM.
For a different take on this week’s NFL action, explore Dimers’ NFL Trends to discover the latest trends in player accessories.
New England Patriots vs. Baltimore Ravens
The The team to pick here is the Ravenswho have a 57% chance of winning their game against the Patriots this Sunday night.
Looking at the betting odds for this Sunday Night Football clash, the Ravens are listed as -2.5 favorites at home, while the Patriots’ moneyline odds are available at +130.
The New England Patriots vs. Baltimore Ravens game at M&T Bank Stadium is scheduled for Sunday, December 21 at 8:20 PM.
San Francisco 49ers vs. Indianapolis Colts
Us The pick to win the final game of Week 16 is the 49erswhich have a 70% chance of winning. Their opponents are expected to have a 30% chance of winning the W.
The San Francisco 49ers vs. Indianapolis Colts at Lucas Oil Stadium is scheduled for Monday, December 22 at 8:15 PM.
For more insight into this week’s NFL predictions, check out the latest from the Dimers Sports Betting Podcast:
NFL instant picks and predictions for week 16
The NFL Week 16 predictions straight up in this article are correct at the time of publication, but may change.
Dimers.com is the best site for NFL predictions, with our clear picks trusted by football fans across the country.
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Please note that all NFL odds and odds listed on this page are subject to change.
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