Elsewhere, City will want to keep the pressure on Arsenal, who were six points behind at the start of the weekend.
Last week they were further adrift when they were held to a draw by Tottenham despite leading 2-0 at half-time.
City will be boosted ahead of the match by the comebacks of several first-team stars who were rested following the Carabao Cup defeat to Newcastle in midweek, with Gianluigi Donnarumma, Erling Haaland and Rodri among those returning.
However, both City and Liverpool are dealing with injury-ravaged defences, meaning fans at Anfield could be treated to something of a goal-fest.
Here’s everything you need to know to follow the action…
How to watch Liverpool vs Man City
TV channel: In the UK, the match will be broadcast live on Sky Sports Main Event, with coverage from 4pm GMT, ahead of the 4.30pm kick-off.
Live stream: Sky Sports subscribers can also watch the match live online via the Sky Go app.
Live blog: You can follow all the matchday action via Standard sport‘s live blog.
Free Highlights: The Sky Sports app and YouTube channel will show highlights from 5.15pm and Match of the Day will air on BBC One at 10.30pm.
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