Giants vs. Patriots NFL MNF odds, preview, picks and predictions

Giants vs. Patriots NFL MNF odds, preview, picks and predictions

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Monday Night Football in Week 13 of the 2025 NFL season is an old rivalry rekindled as the New York Giants visit the New England Patriots. Only New England resembles the Super Bowl contender of recent decades. Currently leading the AFC with a 10-2 record, New York is the exact opposite at 2-10.

Let’s take a look at my Giants vs. Patriots.

Odds between New York Giants and New England Patriots

Moneyline: Giants +280 / Patriots -360
Spread: Giants +7 (-110) / Patriots -7 (-110)
Total: More than 46.5 (-110) / Less than 46.5 (-110)

New York Giants vs. New England Patriots Best Bet No. 1: Patriots -7 (-110)

The gap between these two teams is as wide as their mirror image records suggest. The Patriots are on a nine-game winning streak; the Giants have lost six in a row. There’s no reason to believe these trends won’t continue Monday night. It’s all gone wrong in New York since a brief injection of life came in the form of new quarterback Jaxson Dart taking over from Russell Wilson. Dart has dealt with all kinds of concussions, star receiver Malik Nabers is out for the year with a torn ACL, rookie running back Cam Skattebo suffered a season-ending broken ankle, head coach Brian Daboll was fired a few weeks ago and defensive coordinator Shane Bowen was fired last week. After all that, what’s left of the Giants is a bad team on both sides of the ball. Dart is back after missing the past two games, but he can’t be trusted due to his physical condition and his supporting cast – or lack thereof.

New England, on the other hand, is a well-oiled machine in almost every facet of the game. Head coach Mike Vrabel and quarterback Drake Maye have this franchise in fantastic shape, both in the present and for the future. Vrabel is the current frontrunner for Coach of the Year and Maye enters the MVP discussion as leading the league in passing yards (3,130), with 21 touchdown passes and a QBR that is second-best in the NFL. Defensively, the Patriots rank in the top 10 in overall EPA and are No. 2 in run defense (87.7 yards allowed per play). It’s hard to see this game being competitive, especially in New England.

New York Giants vs. New England Patriots Best Player Prop Bet: TreVeyon Henderson Over 60.5 rushing yards (-110)

This is an excellent spot for Henderson. The Giants have an interim head coach and defensive coordinator, and they were bad against the run even when Daboll and Bowen were around. They are last in the league in both rushing yards per game allowed (157.2) and yards per carry allowed (5.9). No other team is giving up more than 5.3 yards per attempt.

Henderson should be able to take full advantage. The Ohio State product is currently in hot water after scoring five touchdowns in the last three games and running all over Tampa Bay for 147 yards in Week 10. Henderson has gotten 14, 14, 19 and 18 carries in the last four games. RB2 Rhamondre Stevenson has had just one good game this entire series, getting just six carries in Week 12. Their turnover discrepancy could be – and should be – even greater on Monday.

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