What will the resistance be against chemotherapy From a tumor? Responding is today a new test that has been demonstrated to successfully predict those who most likely respond to chemotherapy. The result of the collaboration between the scientists from the University of Cambridge, the Nacional de Investigacions oncológicas Center of Madrid (Cenno) and the Bio Startup Tailor, the test has just been described in one studio Posted Natural genetics And it will be a precious tool to avoid in the future side effects And implement more effective treatment for each individual patient.
Chemotherapy resistance
We know that the chemotherapyThe aim is to destroy cancer cells, is more effective treatments against neoplasmata, but can also be toxic to healthy cells, with side effectsEven seriously. The new test can therefore prevent ineffective chemotherapy patients from being administered and being able to strive for personalized treatments. “Chemotherapy is a pillar of cancer treatment and saves many lives. Yet in many cases it is administered in the same way by outside 40 years“James Brenton remembered among the authors of the study. “Unfortunately, there are too many cases in which the cancer is chemotherapy -resistant, which translates into unpleasant side effects and Scarcity Benefits For the patient. By understanding those who respond earlier, chemotherapy can become a more personalized treatment for different types of cancer “.
How the test works
To predict the resistance to chemotherapy and therefore which patients will not respond to the treatment, the test analyzes changes in the order, structure and the number of copies of the DNA in the tumor, known as known as known as Signatures of Chromosomal Instability (Cin). The study in particular has developed biomarkers based on these signatures of chromosomal instability and the test can accurately predict the resistance to three types chemotherapy: Based on platinum, anthracycline and taxi. “Our technology gives meaning to the genomic chaos observed in many tumors treated with chemotherapy. It connects DNA mutation models with the mechanisms that have caused the damage,” The most important author Geoff Macinttyre explained. “This gives an overview of the defective biology of the tumor, which we can use to resistance To the mechanism of action of the most common chemotherapy “.
Personalized treatments
Once developed i biomarkersThe researchers tested them on data from 840 patients with different types of cancer, which showed their effectiveness. “The times when the chemotherapy It was offered when a ‘universal’ treatment ends “Concluded Iin Foulkes, expert at the UK Cancer Research UK. “Thanks to this research, and to other similar Personalized treatment Cancer will be an option for many patients. Only by offering more optimized and effective treatments can more people lead a longer and better life, free from fear From cancer “.
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