A one -off genmodification can help the body produce its own ‘natural ozempic’, suggests a study.
Researchers in Japan used gene processing to change livers in mice to produce an internal supply of exenatide, the active ingredient in GLP-1 agonist Byetta.
Just like Ozempic and Wegovy, Byetta is an injection that is used to treat type 2 and obesity obesity by regulating blood sugar levels.
After only one treatment, mice could only produce exenatide for a maximum of six months in the study.
Mice that underwent gene processing then received a low -calorie diet to make them obese and to give them prediabetes.
In comparison with mice on the same diet that did not naturally produce exenatide, genetically modified mice less food ate less food, got less weight and responded better to insulin, which regulated their blood sugar levels.
There were also no noticeable side effects, a stark contrast to medicines such as Ozempic, which are linked to gastric paralysis, blindness and organ failure.
Although it is unclear whether the treatment would have the same effect on people, the researchers believe that this could be the first step in making medicines such as Ozempic, which must be taken regularly, a thing of the past.
A new study found that a one-off treatment of gene processing can help the liver produce exenatide, used in GLP-1 drugs (stock image)
The above illustration of the main research author illustrates how the treatment works. The gene is injected into the mice and gives instructions to living cells to produce exenatide. Over time, the mice arrived less and ate less food
The authors of the study, of the University of Osaka, wrote: “This study suggests that the editing of genome can be used to create permanent treatments for complex diseases, which may reduce the need for frequent medication.”
The new research comes as one in eight Americans – 40 million – has reported that he took a GLP -1 agonist as Ozempic at least once and because obesity rates are at 40 percent, a total of around 100 million.
However, as more people turn to GLP-1 drugs, more and more numbers complain about debilitating side effects. Users have reported nausea, vomiting, constipation, stomach paralysis, loss of eyesight and tooth decay.
Users who stop taking these medicines are also susceptible to coming back.
The study, published on Wednesday in the magazine Nature communicationLooked at mice that received diets with a high -calorie right to cause weight gain and prediabetes, a precursor of type 2 diabetes that affects one in three Americans.
With the help of CRISPR technology – a kind of gene process that is usually used for cancer patients – the researchers have placed a gene in the liver cells of the mice that gave them instructions to make exenatide.
Keiichiro Suzuki, senior study author and specially designated professor at the University of Osaka, said: ‘The results were very exciting. We found that these mice processed by genome produced high levels of exenatide that could be detected in blood a few months after the introduction of the gene. ‘
The researchers discovered that mice on treatment were given 34 percent less weight and ate 29 percent less food compared to the control group that received saline solutions.
The mice had also consistently reduced blood sugar levels than checks that can prevent the development of type 2 diabetes.
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The treatment led to a ‘reservoir’ of exenatide in the liver, so there was a steady flow in the bloodstream.
Dr. Suzuki said: ‘An alternative to genome work for many complex and non-genetic diseases are biological medicines, which are essentially injectable proteins.
“These drugs do not stay in the body for long, which means that they usually have to be injected weekly or even daily to maintain consistent therapeutic levels of the medicine.”
The researchers are planning to conduct further studies to evaluate whether the treatment could treat diabetes and other chronic inflammatory disorders as an alternative to injectable GLP-1 drugs.
Dr. Suzuki said, “We hope that our design of a one -off genetic treatment can be applied to many disorders that have no exact genetic causes.”
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