A hidden condition that is suffered by one in four Americans can increase the risk of rapidly rising cancer in young people, suggests an investigation.
Scientists have discovered a connection between colon cancer with early intestine and liver fat, a condition where excessive fat accumulates in the liver.
The disease suffered from 80 to 100 million Americans, the disease often develops quietly and causes minimal or no symptoms – but it can lead to inflammation in the body linked to cancer.
The most common species is caused by alcohol, although sugar-containing diets, obesity and smoking can lead to non-alcoholic liver disease (NAFLD).
The team thought that people younger than 50 with a history of NAFLD up to 24 percent are more likely to develop colon cancer than people without the condition.
And people who showed early signs of the disease had a 12 percent greater risk than people without history of liver disease.
The researchers suggested that the inflammation caused by NAFLD can travel to the colon, can damage cell -DNA and lead to the formation of cancer cells.
The South Korea team said that although more research is needed, early screening for colon cancer must be hired for people with NAFLD.
Bailey Hutchins, a social media -influencer depicted here, died earlier this year of colorectal cancer at the age of 26
In the study of nearly 5 million adults between the ages of 20 to 49, men who also live with NAFLD also had 17 percent more likely than women to be hit by colorectal cancer.
The researchers tied this to men more often smoking and being obese, risk factors for liver disease.
They wrote in the study, said, “Our findings revealed a strong link between NAFLD and early CRC in young adults, which suggests the importance of implementing effective preventive strategies, in particular in populations with a growing burden of metabolic dysfunction.”
The findings come as a stream current of colorectal cancer in young Americans, with rates in less than 50s rise from 8.6 cases per 100,000 people to 13 cases per 100,000 people over the past two decades.
The study, published in the magazine Clinical gastroenterology and hepatologyEvaluated 4.6 million adults in South Korea between the ages of 20 to 49 from a South Korean insurance database.
Of these, 2,733 developed colorectal cancer with early start after an average of nine years.
Each participant underwent routine health controls in 2009 and was followed until 2019.
All participants were grouped in four categories: Nafld, Borderline Nafld or no NAFLD.
Fixed liver is diagnosed by a combination of physical examination, blood tests and imaging studies, including ultrasound, CT scans or MRIs.
About 11 percent were diagnosed with NAFLD, 19 percent were borderline and 70 percent had no history of the condition. Participants in the NAFLD group were usually older and male, smokers and mild to moderate drinkers.
They also tend to have a higher BMI, waist circumference and blood pressure, all risk factors for liver disease.
After taking into account risk factors, patients With NAFLD, a 24 percent increased risk of developing early colon cancer, and the one in the Borderline Nafld group had a 12 percent higher chance compared to people without the condition.
And of those with NAFLD, men were 17 percent more likely than women to develop colorectal cancer.
In addition to men who generally lead unhealthy life, the researchers suggested that the gender distribution could be because it has been shown that the female sex hormone estrogen promotes and protects the growth of healthy bacteria in the intestine.
Smoking, a risk factor for NAFLD, is also more common in men and women more often eat non-inflammatory fruit and vegetables.
NAFLD patients in the twenties were also 24 percent more likely to develop colon cancer than people in the thirty and 11 percent more chance than patients in the forty.
The chance of developing colon cancer was also 18 percent greater for non-diabetics compared to people with diabetes, so that the experts suggest that NAFLD can be a better indicator of the risk of colon cancer than diabetes.
The researchers wrote: “Insofar as we know, this is the first study that provides clinical evidence to support a correlation between NAFLD and Early CRC.”
The team suggested that NAFLD and early colorectal cancer could be connected via shared ‘inflammatory paths’.
Professional baseball player Trey Mancini, depicted here with wife Sara, was diagnosed with three colon cancer at the age of 28, even though they had no symptoms
NAFLD often develops quietly, causing inflammation and a permanent permanent scars from the liver (stock image)
Symptoms of liver fat is difficult to notice in the beginning, other than fatigue. As the disease progresses, symptoms such as swelling, red palms and jaundice appear
NAFLD creates inflammation that damages cell -dna and ensures that cells replicate quickly, increasing the risk of cancer cells.
According to the researchers, chronic liver inflammation also brings off cytokines – signalingsei proteins that communicate with the immune system – that promote cancer cells growth.
NAFLD also disrupts the function of bile acids, which leads to imbalances in intestinal microbioma, a risk factor for colorectal cancer.
In addition, NAFLD increased the risk of tumors specifically at the bottom left of the colon and the rectum, which suggests that the condition focuses on lower areas of the colon and the rectum, although the exact mechanism is unclear.
There were various limitations, including a lack of data about family history, the stage of colon cancer and the history of colonoscopy.
The researchers wrote: “These findings emphasize the need for versatile preventive strategies, including lifestyle interventions and extensive screening for younger populations with NAFLD.”
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