Those gross, waxy things in your ears can actually say a lot about your health.
Researchers in China have identified important differences in the composition of earwax in people with Parkinson’s disease compared to people without the condition, suggesting that the sticky stuff contains secrets that can eventually develop the risk of a person on the ultimate developing condition.
Scientists from the University of Zhejiang took earwax samples from 100 people with Parkinson’s and 79 without. They chose earwax because much of it consists of sebum, an oily substance that undergoes chemical changes in cases of Parkinson’s, and releases various volatile organic compounds (fox).
Parkinson’s triggers neurodegeneration, inflammation and oxidative stress, changing the composition of sebum and creating a clear scent.
It also gradually damages the brain, causing tremors, stiffness and slow movement. Over time, the symptoms worsen to suddenly include freezing, speech loss, swallowing problems – often lead to pneumonia – and falling, both common causes of death in people with that of Parkinson’s.
Four specific types of fox stood out in people with the condition, which suggests that earwax could possibly be an accessible indicator of Parkinson’s, with which patients can prevent invasive diagnostic tests and spinal cranes.
About 1 million Americans and 10 million people worldwide currently have the disease, with nearly 90,000 new cases that are diagnosed every year. Because that number is expected to climb, early diagnosis is more important than ever. Although there is no remedy, medication regimes can be started early to treat symptoms and to delay the progression of the disease.
Researchers in China have identified important differences in the composition of earwax in people with Parkinson’s disease (PD) compared to people without the condition, which suggests that the sticky stuff contains secrets that can mark the risk of a person
Researchers gave the VOC data from the samples of earwax in an algorithm that accurately categorized the status of Parkinson’s status 94 percent of the time, which demonstrates the potential for a fast, reliable diagnostic tool.
The fox that stood out on researchers were all important in distinguishing people with the condition and people without taking age and lifestyle factors even after taking into account.
Two of the fox, ethylbenzene and 4-ethyltoluene are often connections Found in plastics and petroleum Products.
Their presence suggests inflammation in the brain, which is an important engine of the breakdown of dopamine in the brain.
Dopamine, although often considered a ‘feel good’ neurotransmitter, is an important chemical messenger that regulates movement control.
As the dopamine levels fall while Parkinson’s progresses, people become steadily immobile.
Another important VOC was Pentanal, which is produced when fats fall apart.
Increased levels suggest cell damage, a characteristic of Parkinson’s. The connection is linked to An accumulation of proteins Clumps in the brain of patients.
Parkinson’s disease gradually damages the brain and causes tremors, stiffness and slow movement. Over time, the symptoms worsen to suddenly include freezing, dangerous falls, speech loss and swallowing problems
And the VOC 2-Pentadecyl-1.3-Dioxolan probably reflects problems with the metabolism of fats, which come from microbioma changes in the skin of patients.
It is unclear whether this VOC has direct links to PD, but there is a growing amount of research that points to a connection between PD and an imbalance in the intestinal microbiome.
Research suggests that Vos is produced by the balance of good bacteria in the gut, which are also associated with the health of the brain.
An imbalance with which harmful bacteria can flourish, leading to a proliferation of toxins that can cause inflammation in the brain.
Vos comes from a wide range of toxic sources in the environment, pesticides used to grow food, industrial chemicals in gasoline and solvents in everyday items such as chemicals and gluing from dry cleaners to cleaning products, car emissions and contaminated groundwater.
Parkinson’s is supposed to be caused by a confluence of genetic and environmental factors.
It’s the world Fastest growing brain disorderAnd, according to NIH Research, “exposure to environmental oxicants is the main reason.”
In the US, the death of Parkinson’s disease has more than doubled in the last 20 years, with around 35,000 deaths in 2019 compared to 14,500 in 1999.
Parkinson’s death rates rose from 42 to 65 deaths per 100,000 from 1999-2017
Although considering the instructions that earwax can give about the development of Parkinson’s, the investigation of the role that Vos game is not.
A wegid 2023 Meta-analysis Identified different fox present in the breathing and skin oil in people with the disease compared to people without.
These connections are specifically linked to oxidative stress, or a barrage of damage that cells pass before they die.
Dr. Hao Dong, a co-researcher of the recent study, said: ‘This method is a small-scale experiment with one center in China.
“The next step is to conduct further research at different stages of the disease, in multiple research centers and among several ethnic groups, to determine whether this method has a greater practical application value.”
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