Scientists believe that they might have found a cure for diabetes and other debilitating car -immune diseases outside the back of a groundbreaking new study.
Researchers from NYU Langone Health, the Chinese Academy of Sciences and Zhejiang University have looked at why the defense mechanism of the body is watching and turns against us, leaving a trail of incurable, life -changing diseases.
These contain autoimmu art disorders, these include type 1 diabetes (whereby the villain’s immune response in insulin-producing cells in the pancreas) causes damage), multiple sclerosis (MS, where the immune system destroys the protective coating and damage to the liver cells) where the liver cells are destroyed) where the liver cells are destroyed, whereby the liver cells).
Together these diseases meet more than four million Americans, but there are many other car -immune disorders that influence millions more.
Many patients end up on a lifelong cocktail of powerful drugs that can reduce the worst of symptoms, but may have unpleasant side effects, for example, steroids can cause swelling, weight gain and osteoporosis.
But new research suggests that a kind of treatment-lag-3/TCR Bi-specific T-Celpliler or bits possibly mentioned all these incurable disorders could put in their traces by resetting the immune system so that it stops its attacks on healthy tissue.
Some experts predict that this could be one of the greatest progress in the treatment of decades.
Scientists believe that they might have found a cure for diabetes outside the back of a groundbreaking new study
T cells are a type of white blood cell that plays a crucial role in the immune system, patroling in the body, including the bloodstream, to identify and destroy harmful cells and organisms.
But sometimes they may have trouble making a distinction between healthy cells and that cause that disease or illness, such as cancer or autoimmune disorders, so that the T cells accidentally attack healthy tissue.
A way to circumvent this is to tinker with T cells by exposing them to a medicine that changes their DNA, so that they produce a protein called chimere antigen receptor (car).
This protein can more easily detect cancer cells that express and destroy the targeting agent.
As soon as a T-cell becomes a CAR-T cell, it is reproduced in large numbers in the laboratory and injected into the patient’s body a few weeks later to combat cancer cells.
But treatments aimed at T cells are elusive because blocking their action weakens the immune system broadly and creates the risk of infection and cancer.
Car T-cell therapy can also have serious effects on the nervous system, leading to a condition known as immune-sector cell-associated neurotoxicity syndrome (ICANS).
This can lead to symptoms such as headache, confusion, agitation, epileptic seizures and problems with speaking.
However, the new research at mice that are published online in the Journal cell reveals how a newly designed antibody can help with closing T cells in a more effective way and can prevent these harmful side effects.
The research results are based on the presence of T cell receptors (TCRs) and control points.
TCRs are switched on by the body’s own proteins in car -immune diseases.
Checkpoints such as LAG-3 are also engaged by specific signal partners, but when this happens, they suppress the activity of the T-cell.
This means that the power of the T cell to attack other cells, such as cancer cells, is reduced.
By introducing the antibody, it helped to prevent T cells from damaging the body, aimed at regulating their activity and supported the natural immune weather of the body.
This approach is investigated and used in the treatment of various car immune diseases.
In car -immune models of hepatitis, the bits treatment of the T team T -cell infiltration and liver damage reduced.
They also treated mice that were susceptible to the development of multiple sclerosis with short -term, preventive bits prior to the start of disease symptoms, and they reported that bits treated mice had reduced the disease with a standard size.
“Our studies … can promote more-based, spatially guided therapeutic designs such as bits as immunotherapy for other human diseases,” said Co-first author Jia You, a research scientist in Dr. Lab. Cheek.
“Our findings reveal a complicated mechanism that makes a careful treatment approach possible of t-cell autoimmune diseases, which currently do not miss effective immunotherapies,” said Co-Senior study author Dr. Jun Wang, university lecturer in the Pathology department at the NYU Grossman School of Medicine.
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